Human Male AB Serum

Human Male AB Serum, a blood-derived material collected from male donors with AB blood type, is a versatile supplement for cell culture applications by supporting robust cell proliferation through essential nutrients and growth factors.

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Enhance Your Cell Culture Performance

Learn how Human Male AB Serum Can Accelerate Your Cell Culture

Ideal for Human Cell Lines: Male AB human serum serves as an alternative for fetal bovine serum (FBS), which is not an ideal supplement for human-derived cell lines. Additionally, its use is discouraged by regulatory agencies (e.g., EMA/410/01) due to the risk of transmitting xenogenic agents and zoonotic infections.¹
Manufactured for Quality and Consistency: Grifols Bio Supplies Male AB human serum (formerly Access Biologicals' product) is collected at FDA- and EMA-licensed centers within the United States and manufactured following a cGMP process under a strict quality assurance system, enhancing product safety.
Eliminating Risk of Reactions: This serum lacks antibodies against the A and B blood type antigens. This prevents reactions with cultured cells, making it an ideal option for use in biomedical applications.
Absence of Rhesus Factor Antibodies: Collected exclusively from male donors, Grifols Bio Supplies Male AB human serum is free of Rhesus factor antibodies, enhancing product safety. These antibodies can impact the safety of the final product.

1. Shih DT, Burnouf T. Preparation, quality criteria, and properties of human blood platelet lysate supplements for ex vivo stem cell expansion. N Biotechnol. 2015;32(1):199-211.

Product Options and Specifications

Find the Human Male AB Serum that Matches Your needs

Grifols Bio Supplies offers a range of human male AB serum options to cater to your specific cell culture needs. Here's a quick overview of the key differences:

PD vs. OTC:

Plasma-derived (PD) serum is the most common male AB serum and facilitates scaled cell culture manufacturing of cell therapies.
Off-the-clot (OTC) serum, derived from whole blood donations, is rich in growth factors and ideal for early stage manufacturing, process development, and R&D of cell culture applications.

Xeno-Free:

Xeno-free serum is free of xenogenic components (animal-derived materials). This serum enables a smooth regulatory process using only human-derived materials.

The detailed table below provides a comprehensive comparison of product specifications to help you select the optimal human male AB serum for your cell culture.

Product Information

Human Male AB Serum PD

Human Male AB Serum OTC Xeno-free

Human Male AB Serum PD Xeno-free

Product Code

Human Male AB Serum PD: 515

Human Male AB Serum OTC Xeno-free: 516

Human Male AB Serum PD Xeno-free: 535

Thrombin

Human Male AB Serum PD: Bovine

Human Male AB Serum OTC Xeno-free: N/A

Human Male AB Serum PD Xeno-free: Human (pharma grade)

Grade

Human Male AB Serum PD: GMP

Human Male AB Serum OTC Xeno-free: GMP

Human Male AB Serum PD Xeno-free: GMP

Source

Human Male AB Serum PD: Plasma derived (PD)

Human Male AB Serum OTC Xeno-free: Whole blood (off-the-clot; OTC)

Human Male AB Serum PD Xeno-free: Plasma derived (PD)

Product Packaging

Human Male AB Serum PD

Human Male AB Serum OTC Xeno-free

Human Male AB Serum PD Xeno-free

Bottles

Human Male AB Serum PD: 100 mL and 500 mL

Human Male AB Serum OTC Xeno-free: 100 mL and 500 mL

Human Male AB Serum PD Xeno-free: 100 mL and 500 mL

Sterile Weldable Bag

Human Male AB Serum PD: No

Human Male AB Serum OTC Xeno-free: Available

Human Male AB Serum PD Xeno-free: Available

Regulations

Human Male AB Serum PD

Human Male AB Serum OTC Xeno-free

Human Male AB Serum PD Xeno-free

Collection Centers

Human Male AB Serum PD: FDA approved

Human Male AB Serum OTC Xeno-free: FDA approved

Human Male AB Serum PD Xeno-free: FDA and EMA approved

Donor Viral Testing

Human Male AB Serum PD: FDA and EU compliant

Human Male AB Serum OTC Xeno-free: FDA and EU compliant

Human Male AB Serum PD Xeno-free: FDA and EU compliant

Customizations

Human Male AB Serum PD

Human Male AB Serum OTC Xeno-free

Human Male AB Serum PD Xeno-free

Heat Inactivation

Human Male AB Serum PD: Available

Human Male AB Serum OTC Xeno-free: Available

Human Male AB Serum PD Xeno-free: Available

Gamma Irradiation

Human Male AB Serum PD: Available

Human Male AB Serum OTC Xeno-free: Available

Human Male AB Serum PD Xeno-free: Available

Intended Use

Human Male AB Serum PD

Human Male AB Serum OTC Xeno-free

Human Male AB Serum PD Xeno-free

Stage of use

Human Male AB Serum PD: R&D

Human Male AB Serum OTC Xeno-free: R&D and early clinical

Human Male AB Serum PD Xeno-free: Clinical and scaled commercial

Scalability

Human Male AB Serum PD: Yes

Human Male AB Serum OTC Xeno-free: No

Human Male AB Serum PD Xeno-free: Yes

Complementary Documentation

Human Male AB Serum PD

Human Male AB Serum OTC Xeno-free

Human Male AB Serum PD Xeno-free

Viral Inactivation Validation Study

Human Male AB Serum PD: No

Human Male AB Serum OTC Xeno-free: No

Human Male AB Serum PD Xeno-free: Yes

	Human Male AB Serum PD	Human Male AB Serum OTC Xeno-free	Human Male AB Serum PD Xeno-free
Product Information
Product Code	515	516	535
Thrombin	Bovine	N/A	Human (pharma grade)
Grade	GMP	GMP	GMP
Source	Plasma derived (PD)	Whole blood (off-the-clot; OTC)	Plasma derived (PD)

Product Packaging
Bottles	100 mL and 500 mL	100 mL and 500 mL	100 mL and 500 mL
Sterile Weldable Bag	No	Available	Available

Regulations
Collection Centers	FDA approved	FDA approved	FDA and EMA approved
Donor Viral Testing	FDA and EU compliant	FDA and EU compliant	FDA and EU compliant

Customizations
Heat Inactivation	Available	Available	Available
Gamma Irradiation	Available	Available	Available

Intended Use
Stage of use	R&D	R&D and early clinical	Clinical and scaled commercial
Scalability	Yes	No	Yes

Complementary Documentation
Viral Inactivation Validation Study	No	No	Yes

Key Benefits

Unleash Your Research Potential

Superior Cell Growth

Male AB serum is a rich source of nutrients for robust cell proliferation

Enhanced Safety

Every unit undergoes rigorous testing using FDA-approved methods to ensure absence of all required viral markers.

Additional testing for mycoplasma, endotoxin, and other parameters is performed

Product Consistency

Large lot production supports consistent results, minimizing variability and promoting reproducibility

Global Regulatory Support

Gamma irradiation viral clearance study and plasma sourced from dual FDA- and EMA-approved collection centers simplify regulatory submissions and registrations

Let Grifols be your trusted partner

Contact a Grifols representative today to get more information.

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